Abstract: ​​​​​​​In some regions around the globe, landscapes are being converted from natural habitats into a mosaic of agriculture and other human-dominated landscapes. In other areas, human-dominated landscapes are being restored for various biodiversity or carbon capture targets. These shifts in land use impact plant and animal species – and concomitant to this change in biodiversity is a change in abundance and diversity of the pathogens that infect the animals and plants remaining. Transmission of a pathogen can decline or increase due to changes in availability of suitable hosts, changes in the abiotic environment, altered movement of hosts or some other impact of changing landscapes.  We currently lack the ability to accurately predict the response of a particular pathogen in a landscape undergoing conversion. In this talk, I will give an overview of theory and study systems we are using to disentangle factors affecting pathogens in changing landscapes.  I will discuss modular multi-scale models that we have been using to forecast Hendra virus shedding and spillover risk from flying foxes in Australia.  Then I will give an overview of small mammal field studies in Uganda and Scotland and the pathogens and parasites we are tracking across deforestation and restoration gradients.  The aim of this research is to identify underlying host, parasite, and environmental traits that are important for predicting short-term and long-term responses to land conversion.